癌症治疗中过继性细胞疗法小结
其他

from:Challenges and new technologies in adoptive cell therapy

Zhang et al.  Journal of Hematology & Oncology (2023) 16:97.  https://doi.org/10.1186/s13045-023-01492-8

当前常见的过继性细胞疗法包括:

- 适应性免疫细胞(Adaptive immune cell)

-- TILs,Tumor-infiltrating lymphocytes,肿瘤浸润淋巴细胞

-- TCR-T,T-cell receptor–engineered/modified T-cell,T细胞受体嵌合T细胞

-- CAR-T,Chimeric antigen rerceptor T-cell,嵌合抗原受体T细胞

- 固有免疫细胞(Innate immune cell)

-- CAR-NK,CAR-natural killer

-- CAR-M,CAR-macrophage

-- CAR-γδT

-- CAR-NKT,CAR-natural killer T


Fig. 1 Summary of current adoptive cell therapies in cancer treatment. 

- Th, helper T cell;  辅助性T细胞

- CTL, cytotoxic T lymphocyte;  细胞毒性T淋巴细胞;

- PBMC, peripheral blood mononuclear cell; 外周血单个核细胞;

- iPSC, induced pluripotent stem cell; 诱导多能干细胞;

- hESC, human embryonic stem cell; 人胚胎干细胞;

- UCB, umbilical cord blood; 脐带血;

- hPSC, human pluripotent stem cell; BM, bone marrow; 人多能干细胞hPSC;BM,骨髓;

- ADCC, antibody-dependent cell-mediated cytotoxicity; 抗体依赖性细胞介导的细胞毒性;

- CRS, cytokine release syndrome; 细胞因子释放综合征;

- ICANS, immune effector cell-associated neurotoxicity syndrome; 免疫效应细胞相关神经毒性综合征;

- GvHD, graft versus host disease; 移植物抗宿主病;

- MMP, matrix metalloproteinase; 基质金属蛋白酶;

- ECM, extracellular matrix; 细胞外基质;

- RV, retrovirus; 逆转录病毒;

- LV, lentivirus; 慢病毒;

- AdV, adenovirus 腺病毒